藍細菌廣泛分布于海洋、陸地、淡水和極地等生態系統中，是研究微生物環境適應機制的重要模式體系。在光合生物制造過程中，藍細菌細胞工廠同樣需要面對各種逆境脅迫的挑戰。因此，解析藍細菌對逆境脅迫的適應機制具有重要的科學和技術意義。
微生物制造工程中心采集豐富的藻種資源，應用合成生物技術、系統生物技術、生物化學及分子生物學等多維手段對藍細菌抵抗逆境脅迫的分子模式進行解析。針對藍細菌高鹽耐受機制，從"感知-傳導-調控-代謝”等多個層面上進行系統研究，揭示了聚球藻 PCC 7942 細胞通過“離子濃度介導的酶活協同調控”機制，快速調節蔗糖合成過程中“合成酶-降解酶”酶活以積累蔗糖、平衡胞內外滲透壓差的適應策略。針對藍細菌高溫高光耐受機制，發現細胞能量代謝核心模塊 FoF1-ATP 合成酶對高溫高光耐受性具有重要影響，其 alpha 亞基上單一氨基酸突變（C252Y）即可賦予藻株適應高溫高光脅迫并快速積累生物質的能力。
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