The researchers have revealed an interesting biosynthetic mechanism of natural products in filamentous fungi. A new mode of coordinated crosstalk between two separate gene clusters containing four core-biosynthetic genes to generate the new azaphilone compounds was observed in Aspergillus terreus. This is a meaningful mechanism of fungal secondary metabolism, which allows fungi to synthesize more complex compounds and gain new physiological functions. The results provide a new insight into fungal natural product biosynthesis.